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Some patients find extended-release metformin easier to tolerate due to less severe gastrointestinal side effects

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This metabolite was discovered to mitigate ectopic lipid deposition in renal tubular cells, indicating the presence of a gut microbiota5-OPkidney axis (potentially mediated by Clostridium5-OPELD), which may serve as a novel intervention target (Steven et al., 2017

Venous blood samples were obtained before and after 8 weeks

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